Biosynthesis of the mitochondrial adenine nucleotide translocase (ATPase) inhibitor bongkrekic acid in Burkholderia gladioli.
نویسندگان
چکیده
Biosynthetic studies with (13)C-labelled acetates and methionine revealed that the infamous, food-related toxin bongkrekic acid from Burkholderia gladioli is a polyketide with acetate-derived beta-branches and a carboxylate terminus derived from the methyl group of an acetate.
منابع مشابه
Bongkrekic acid. An inhibitor of the adenine nucleotide translocase of mitochondria.
The antibiotic bongkrekic acid is shown to inhibit the phosphorylation of added ADP coupled with either the reactions of the respiratory chain or the dismutation of oc-ketoglutarate in mammalian mitochondria. It also prevents the utilization of ATP for energy-linked cation transport and in energy dissipation by uncoupling agents. However, bongkrekic acid does not inhibit the Mg++-requiring ATPa...
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 8 7 شماره
صفحات -
تاریخ انتشار 2010